Table 4 List of input data for the evaluation of exposure and risk (Eqs. (1) to (4)).

From: Novel metallomic profiling and non-carcinogenic risk assessment of botanical ingredients for use in herbal, phytopharmaceutical and dietary products using HR-ICP-SFMS

Input parameter(s)

Abbreviation

Value

Unit(s)

References

Estimated daily intake

EDI

mg (kg BW)−1d−1

8,13

Concentration

C

mg kg−1

8,13

Body weight (adult; European default value)

BW

70

kg

14

Ingestion/intake rate

IR

Low

0.0002

kg day−1

13

High

0.2

15

Exposure frequency

EF

90

days

8,13

Exposure duration

ED (shorter-than-lifetime)

20

years

8,13

ED (average lifetime)

70

years

Transfer rate (metal)

t

Cd

Cu

Pb

14

%

8,13

Hg

24

All other elements

10

Average exposure time (average lifetime (ED) = 365 days × 70 years)

AT

25,550

days

8,13

Reference dose (oral)

RfD

Cd (1.00 × 10–3)

Cr (3.00 × 10–3)

Cu (4.00 × 10–2)

Mn (4.6 × 10–2)

Ni (2.00 × 10–2)

Pb (3.50 × 10–3)

mg kg−1 day−1

11,16

Oral carcinogenic slope factor (SF)

SF

Cd (0.38)

Cr (0.5)

Pb (8.5 × 10–3)

Ni (0.84)

mg kg−1 day−1

16,17