Table 2 The relation between laboratory findings and severity (No. = 267).

From: Coagulation parameters abnormalities and their relation to clinical outcomes in hospitalized and severe COVID-19 patients: prospective study

Laboratory findings

Severity

P-value

Non-severe (no. = 196)

Severe (no. = 71)

WBCs (4–11 × 109/L)

Mean ± S.D

7.59 ± 3.33

7.94 ± 3.74

0.722

Median (range)

6.9 (2.6–21)

6.9 (2–19.7)

Neutrophils (45–75%)

Mean ± S.D

65 ± 17.19

69.06 ± 12.56

0.093

Median (range)

65 (29–96)

71 (30–90)

Lymphocytes (20–45%)

Mean ± S.D

29.4 ± 16.41

21.23 ± 13.53

 < 0.001

Median (range)

30 (2–66)

18 (3–62)

NLR (1–3)

Mean ± S.D

4.79 ± 6.6

5.71 ± 5.61

 < 0.001

Median (range)

2.22 (0.45–48)

3.88 (0.48–30)

HB (F:12–14 g/dl M:14–16 g/dl)

Mean ± S.D

12.97 ± 1.7

11.61 ± 1.74

 < 0.001

Median (range)

13.1 (8–16.5)

11.7 (8.2–15.6)

MCV (77–96 fl)

Mean ± S.D

80.33 ± 6.66

77.14 ± 5.81

 < 0.001

Median (range)

81.7 (60–95.4)

77.3 (64.5–87.8)

MCH (26–32 pg)

Mean ± S.D

24.88 ± 3.1

24.17 ± 2.55

0.093

Median (range)

25 (18–31.6)

24 (18–30.1)

PLT (150–400 × 109/L)

Mean ± S.D

267.91 ± 79.34

245.06 ± 118.36

0.494

Median (range)

258 (30–534)

271 (31–448)

Ferritin (30–160 ng/mL)

Mean ± S.D

275.08 ± 162.31

445 ± 260.65

 < 0.001

Median (range)

253.67 (11.9–1105.23)

363 (158–1295)

LDH (100–190 IU/L)

Mean ± S.D

346.63 ± 123.82

608.61 ± 242.81

 < 0.001

Median (range)

339.5 (75–685)

578 (156.3–1553)

D-dimer (0–0.5 mg/L)

Mean ± S.D

0.65 ± 0.78

3.43 ± 2.5

 < 0.001

Median (range)

0.3 (0.1–4.8)

2.7 (0.34–14.01)

CRP (< 6 mg/L)

Mean ± S.D

14.75 ± 17.98

39.62 ± 53.7

 < 0.001

Median (range)

6 (0–96)

24 (3–384)

PC (70–120%)

Mean ± S.D

85.75 ± 10.97

76.27 ± 17.5

 < 0.001

Median (range)

85 (34.5–110)

80 (30.3–100)

aPTT (25–31 s)

Mean ± S.D

30.98 ± 5.2

42.08 ± 17.01

 < 0.001

Median (range)

30.5 (24.5–82)

34.1 (24.5–97.5)

AT-III (80–120%)

Mean ± S.D

90.33 ± 9.57

79.11 ± 10.2

 < 0.001

Median (range)

90 (60–118)

78 (50–97)

Fibrinogen (2–4 g/L)

Mean ± S.D

3.61 ± 0.86

4.49 ± 0.9

 < 0.001

Median (range)

3.59 (2–5.7)

4.66 (0–6.1)

 

ESR

Mean ± S.D

22.02 ± 14.71

43.24 ± 24.12

 < 0.001

Median (range)

18 (6–130)

42 (5–150)

  1. WBCs white blood cells, Hb hemoglobin, NLR neutrophil-to-lymphocyte ratio, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, PLT platelets, LDH lactate dehydrogenase, ESR erythrocyte sedimentation rate, CRP C-reactive protein, PC prothrombin concentration, aPTT activated partial thromboplastin, AT-III antithrombin-III.
  2. P-value was calculated by Mann Whitney test.
  3. P-value < 0.05 is statistically significant.
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