Table 3 Cross-classification of predicted risk of breast cancer among the whole study population, according to the percentiles of each PRS.

From: Assessing agreement between different polygenic risk scores in the UK Biobank

Percentiles of PRS-A (%)

Percentiles of PRS-B

 

 < 1%

1–20%

20–40%

40–60%

60–80%

80–99%

 ≥ 99%

 < 1

345 (20.1, 20.1, 0.2)

1140 (66.5, 3.5, 0.7)

176 (10.3, 0.5, 0.1)

44 (2.6, 0.1, 0.0)

9 (0.5, 0.0, 0.0)

1 (0.1, 0.0, 0.0)

0 (0.0, 0.0, 0.0)

1–20

1117 (3.4, 65.1, 0.7)

15,409 (47.3, 47.3, 9.0)

8818 (27.1, 25.7, 5.1)

4696 (14.4, 13.7, 2.7)

2052 (6.3, 6.0, 1.2)

490 (1.5, 1.5, 0.3)

1 (0.0, 0.1, 0.0)

20–40

198 (0.6, 11.5, 0.1)

8788 (25.6, 27.0, 5.1)

9989 (29.1, 29.1, 5.8)

8053 (23.5, 23.5, 4.7)

5210 (15.2, 15.2, 3.0)

2051 (6.0, 6.3, 1.2)

9 (0.0, 0.5, 0.0)

40–60

43 (0.1, 2.5, 0.0)

4648 (13.6, 14.3, 2.7)

7998 (23.3, 23.3, 4.7)

8908 (26.0, 26.0, 5.2)

8050 (23.5, 23.5, 4.7)

4607 (13.4, 14.1, 2.7)

44 (0.1, 2.6, 0.0)

60–80

11 (0.0, 0.6, 0.0)

2098 (6.1, 6.4, 1.2)

5296 (15.4, 15.4, 3.1)

7988 (23.3, 23.3, 4.7)

10,047 (29.3, 29.3, 5.9)

8688 (25.3, 26.7, 5.1)

170 (0.5, 9.9, 0.1)

80–99

1 (0.0, 0.1, 0.0)

497 (1.5, 1.5, 0.3)

2006 (6.2, 5.8, 1.2)

4574 (14.0, 13.3, 2.7)

8736 (26.8, 25.5, 5.1)

15,674 (48.1, 48.1, 9.1)

1095 (3.4, 63.8, 0.6)

 ≥ 99

0 (0.0, 0.0, 0.0)

3 (0.2, 0.0, 0.0)

15 (0.9, 0.0, 0.0)

35 (2.0, 0.1, 0.0)

194 (11.3, 0.6, 0.1)

1072 (62.5, 3.3, 0.6)

396 (23.1, 23.1, 0.2)

  1. Number of participants are shown as n (col%, row%, cell%). Higher percentiles of PRS indicate increased risk of breast cancer; “≥ 99%” percentile corresponds to the top 1% risk.
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