Table 1 Clinical and histopathological characteristics of scalp melanoma patients according to the presence of androgenetic alopecia.
Variable | Alopecia (no) | Alopecia (yes) | p | Elastosis (no) | Elastosis (yes) | p |
|---|---|---|---|---|---|---|
Sex, n (%) | ||||||
Male 0 | 18 (69.2) | 20 (90.9) | 0.084* | 13 (59.1) | 25 (96.2) | 0.003* |
Female 1 | 8 (30.8) | 2 (9.1) | 9 (40.9) | 1 (3.8) | ||
Age (years) | ||||||
Mean ± SD | 52.27 ± 17.20 | 73.18 ± 9.03 | < 0.001** | 50.81 ± 18.16 | 71.19 ± 9.89 | < 0.001** |
Median (min–max) | 56.50 (20.0–78.0) | 74.50 (57.0–86.0) | 55 (20.0–86.0) | 73 (45–86) | ||
Chronic sun damage, n (%) | ||||||
No | 19 (76) | 2 (9.1) | < 0.001**** | 15 (71.4) | 6 (23.1) | 0.003**** |
Yes | 6 (24) | 20 (90.9) | 6 (28.6) | 20 (76.9) | ||
History of melanoma, n (%) | ||||||
No | 18 (69.2) | 17 (77.3) | 0.765**** | 14 (63.6) | 21 (80.8) | 0.315**** |
Yes | 8 (30.8) | 5 (22.7) | 8 (36.4) | 5 (19.2) | ||
Family history of melanoma, n (%) | ||||||
No | 21 (80.8) | 21 (95.5) | 0.199* | 17 (77.3) | 25 (96.2) | 0.081* |
Yes | 5 (19.2) | 1 (4.5) | 5 (22.7) | 1 (3.8) | ||
Skin phototype, n (%) | ||||||
1 | 0 (0) | 1 (4.8) | 0.617* | 0 (0) | 1 (4.2) | 0.999* |
2 | 18 (75) | 14 (66.7) | 15 (71.4) | 17 (70.8) | ||
3 | 6 (25) | 6 (28,6) | 6 (28.6) | 6 (25) | ||
Localization, n (%) | ||||||
Parietal | 12 (48) | 13 (65) | 0.045* | 10 (47.6) | 15 (62.5) | 0.200* |
Frontal | 0 (0) | 4 (20) | 1 (4.8) | 3 (12.5) | ||
Vertex | 6 (24) | 2 (10) | 5 (23.8) | 3 (12.5) | ||
Occipital | 3 (12) | 1 (5) | 1 (4.8) | 3 (12.5) | ||
Nuchal | 1 (4) | 0 (0) | 1 (4.8) | 0 (0) | ||
Temporal | 3 (12) | 0 (0) | 3 (14.3) | 0 (0) | ||
Tumor subtype, n (%) | ||||||
Superficial spreading | 23 (88.5) | 11 (52.4) | 0.001* | 20 (90.9) | 14 (56.0) | 0.003* |
Nodular | 1 (3.8) | 1 (4.8) | 0 (0) | 2 (8.0) | ||
Lentigo maligna | 0 (0) | 7 (33.3) | 0 (0) | 7 (28.0) | ||
Desmoplastic | 1 (3.8) | 0 (0) | 1 (4.5) | 0 (0) | ||
Other | 1 (3.8) | 2 (9.6) | 1 (4.5) | 2 (8.0) | ||
Breslow thickness (mm) | ||||||
Mean ± SD | 1.53 ± 2.09 | 1.34 ± 2.75 | 0.186*** | 1.65 ± 2.45 | 1.27 ± 2.38 | 0.190*** |
Median (min–max) | 0.6 (0–7.1) | 0 (0–9.6) | 0.7 (0–9.6) | 0.15 (0–9) | ||
Associated nevus, n (%) | ||||||
No | 21 (80.8) | 17 (77.3) | 0.999* | 16 (72.7) | 22 (84.6) | 0.47* |
Yes | 5 (19.2) | 5 (22.7) | 6 (27.3) | 4 (15.4) | ||
Ulceration, n (%) | ||||||
No | 23 (88.5) | 21 (95.5) | 0.614* | 20 (90.9) | 24 (92.3) | 0.999* |
Yes | 3 (11.5) | 1 (4.5) | 2 (9.1) | 2 (7.7) | ||
Mitosis, n (%) | ||||||
No | 17 (65.4) | 18 (81.8) | 0.202**** | 14 (63.6) | 21 (80.8) | 0.183**** |
Yes | 9 (34.6) | 4 (18.2) | 8 (36.4) | 5 (19.2) | ||
Perineural invasion, n (%) | ||||||
No | 26 (100) | 20 (90.9) | 0.205* | 21 (95.5) | 25 (96.2) | 0.999* |
Yes | 0 (0) | 2 (9.1) | 1 (4.5) | 1 (3.8) | ||
Elastosis, n (%) | ||||||
No | 20 (76.9) | 2 (9.1) | < 0.001**** | |||
Yes | 6 (23.1) | 20 (90.1) | ||||
Classic dermoscopic pattern | ||||||
Mean ± SD | 2.54 (1.28) | 2.5 (1.70) | 0.828*** | 2.55 (1,27) | 2.5 (1.64) | 0.81*** |
Median (min–max) | 2 (1–5) | 2 (0–6) | 2 (1–5) | 2 (0–6) | ||
Photodamaged dermoscopic pattern | ||||||
Mean ± SD | 1.04 ± 1.75 | 2.95 ± 1.93 | < 0.001*** | 0.55 ± 0.99 | 3.04 ± 2.03 | < 0.001*** |
Median (min–max) | 0 (0–7) | 2.5 (0–8) | 0 (0–4) | 3 (0–8) | ||
BRAF V600K | ||||||
No | 15 (75) | 15 (83.3) | 0.697* | 13 (81.2) | 17 (77.3) | 0.999* |
Yes | 5 (25) | 3 (16.7) | 3 (18.8) | 5 (22.7) | ||
BRAF V600E | ||||||
No | 15 (75) | 18 (100) | 0.048* | 11 (68.8) | 22 (100) | 0.009* |
Yes | 5 (25) | 0 (0) | 5 (31.2) | 0 (0) | ||
KIT | ||||||
No | 19 (95) | 17 (94.4) | 0.999* | 15 (93.8) | 21 (95.5) | 0.999* |
Yes | 1 (5) | 1 (5.6) | 1 (6.2) | 1 (4.5) | ||
NF1 | ||||||
No | 10 (66.7) | 19 (90.5) | 0.103* | 8 (61.5) | 21 (91.3) | 0.073* |
Yes | 5 (33.3) | 2 (9.5) | 5 (38.5) | 2 (8.7) | ||
NRAS | ||||||
No | 20 (100) | 16 (88.9) | 0.218* | 16 (100) | 20 (90.9) | 0.499* |
Yes | 0 (0) | 2 (11.1) | 0 (0) | 2 (9.1) | ||
