Table 2 Durations of social interactions between male and female rats during pairing session.

From: Increased self-triggered vocalizations in an epidermal growth factor-induced rat model for schizophrenia

 

Control rats

EGF rats

Factors

Average

SD

n

Average

SD

n

2-month *

26.4

11.2

17

25.4

13.5

18

3-month #

32.5

13.3

14

31.3

8.0

13

3-month + risperidone

62.7***, ###

23.0

10

76.2***, ###

16.1

11

  1. The time a male rat spent sniffing a female rat was counted during the latter half of the pairing period (i.e., 5 min). The male rat was also exposed to two other female rats. A mean sniffing duration (sec) was calculated from the three pairing experiments. “n” represents the number of male rats examined. Two-way ANOVA with the main factors of condition (2-month, 3-month, and 3-month plus risperidone) and treatment (EGF and saline) revealed a main effect of condition (F1,77 = 64.5; p < 0.001) without an interaction (F2,77 = 1.980; p = 0.145) or an effect of treatment (F1,77 = 1.465; p = 0.230). Tukey LSD suggested post-hoc differences between the 3-month and risperidone groups (***p < 0.001) and between the 2-month and risperidone groups (###p < 0.001).
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