Figure 2

Normalized within-network connectivity estimates for significant interactions between AUDIT group and rs1042044 genotype. Top panels (brain images) include the component T-map extracted during the ICA processing step; colors represent T-max values. High-AUDIT: AUDIT total score ≥ 8 (n = 96); Low-AUDIT: AUDIT total score < 8 (n = 85). A is the risk allele; A-allele carriers: AA + AC (n = 114); Non-A-allele carriers: CC (n = 67). IC8 (hypothalamus/brainstem; A), IC45 (thalamus/3rd ventricle; B), and IC54 (pcc/tpj/occipital/mpfc; C) were mapped onto the dorsal default mode network; IC46 (thalamus/brainstem; D) was mapped onto the basal ganglia network.