Table 3 Diagnostic utility of biomarkers of AEs of IIPs and SIPs.

From: Assessment of diagnostic utility of serum hemeoxygenase-1 measurement for acute exacerbation of interstitial pneumonias

 

Variable

N

AUC

Best cut-off values

Sensitivity, %

Specificity, %

P values

IIPs

Serum HO-1, ng/mL

90

0.87

22.8

87

74

 < 0.001

Serum LDH, U/L

90

0.78

233

78

76

 < 0.001

Serum SP-D, ng/mL

68

0.59

203

53

74

0.043

Serum KL-6, U/mL

84

0.57

838

47

75

0.071

Honeycomb score, points

90

0.52

8

28

82

0.773

GGO score, points

90

0.88

6

84

85

 < 0.001

SIPs

Serum HO-1, ng/mL

32

0.86

20.5

89

74

0.012

Serum LDH, U/L

32

0.60

393

33

91

0.200

Serum SP-D, ng/mL

19

0.63

207

63

73

0.440

Serum KL-6, U/mL

28

0.43

2931

100

15

0.656

Honeycomb score, points

32

0.64

6

33

91

0.129

GGO score, points

32

0.78

5

78

83

0.008

  1. AE, acute exacerbation; AUC, area under the receiver operating characteristic curve; GGO, ground-glass opacity; HO-1, heme oxygenase-1; IIPs, idiopathic interstitial pneumonias; KL-6, Krebs von den Lungen-6; LDH, lactate dehydrogenase; SIPs, secondary interstitial pneumonias; SP-D, surfactant protein-D.
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