Table 1 Gene Ontology (GO) terms of genes enriched by CuleGO analysis.

From: Profiling of gene expression in the brain associated with anxiety-related behaviors in the chronic phase following cranial irradiation

Process

Term ID

Term name

No. of Genes

Associated genes found

Cell cycle

GO:2000134

Negative regulation of G1/S transition of mitotic cell cycle

3

Cdkn1a, Klf4, Plk3

Angiogenesis

GO:0016525

Negative regulation of angiogenesis

6

Cd59a, Gadd45a, Gm20498, Klf2, Klf4, Thbs4

Spliceosome

GO:0071005

U2-type precatalytic Spliceosome

3

Cwc27, Lsm5, Lsm8

Response to radiation

GO:0071479

Cellular response to Ionizing radiation

4

Cdkn1a, Egr1, Gadd45a, Hspa5

Transport

GO:0089718

Amino acid import Across plasma membrane

3

Ntsr1, Per2, Slc6a13

Metabolic process

GO:1901800

Positive regulation of proteasomal protein catabolic process

6

Hspa1b, Klhl40, Nupr1, Plk3, Trib1, Trib2

Hormone metabolic process

GO:0046886

GO:0050810

Positive regulation of hormone biosynthetic process

regulation of steroid biosynthetic process

3

4

Bmp6, Egr1, Gh

Bmp6, Egr1, Gh, Nr1d1

Response to steroid hormone

GO:0051384

GO:0051412

Response to glucocorticoid

Response to corticosterone

8

4

Bmp6, Cdkn1a, Crh, Dusp1, Fos, Fosb, Ptgds, Sstr2

Cdkn1a, Crh, Fos, Fosb

Protein folding

GO:0061077

GO:0051085

Chaperone-mediated protein folding

Chaperone cofactor-Dependent protein refolding

6

4

Dnajb5, Hspa1b, Hspa5, Hspb1, Pdia4, Sdf2l1

Dnajb5, Hspa1b, Hspa5, Sdf2l1

Steroid hormone secretion

GO:0032370

GO:0035930

GO:2000848

Positive regulation of Lipid transport

Corticosteroid hormone secretion

Positive regulation of corticosteroid hormone secretion

4

3

3

Bmp6, Crh, Ecrg4, Ntsr1

Bmp6, Crh, Ecrg4

Bmp6, Crh, Ecrg4

Cell differentiation

GO:0014812

GO:0032642

GO:0014910

GO:0002763

GO:0042531

Muscle cell migration

regulation of Chemokine production

Regulation of smooth muscle cell migration

Positive regulation of myeloid leukocyte differentiation

Positive regulation of tyrosine phosphorylation of STAT protein

6

4

4

5

3

Ccl5, Ccn3, Egr1, Nr4a3, Thbs4, Trib1

Ccl5, Csf1r, Egr1, Klf4

Ccl5, Egr1, Nr4a3, Trib1

Ccl5, Csf1r, Fos, Klf10, Trib1

Ccl5, Csf1r, Gh

Behavior

GO:0042752

GO:0050795

GO:0048512

GO:0042745

GO:0042749

GO:0004879

Regulation of circadian rhythm

Regulation of behavior

Circadian behavior

Circadian sleep/wake cycle

Regulation of circadian Sleep/wake cycle

Nuclear receptor activity

6

5

5

3

3

3

Cort, Klf10, Nr1d1, Per2, Ptgds, Sik1

Cort, Crh, Nr1d1, Nr4a3, Ptgds

Ciart, Cort, Egr1, Nr1d1, Ptgds

Cort, Nr1d1, Ptgds

Cort, Nr1d1, Ptgds

Nr1d1, Nr4a1, Nr4a3

Kinase activity

GO:0033549

GO:0007492

GO:0004860

GO:0006469

GO:0043407

GO:0071901

MAP kinase Phosphatase activity

Endoderm development

Protein kinase inhibitor activity

Negative regulation of Protein kinase activity

Negative regulation of MAP kinase activity

Negative regulation of Protein serine/threonine kinase activity

4

4

5

11

5

7

Dusp1, Dusp4, Dusp5, Dusp6

Arc, Dusp1, Dusp4, Dusp5

Cdkn1a, Hspb1, Spry4, Trib1, Trib2

Cdkn1a, Dusp1, Dusp4, Dusp5, Dusp6, Gadd45a, Hspb1, Shb, Spry4, Trib1, Trib2

Dusp1, Dusp4, Dusp5, Dusp6, Spry4

Cdkn1a, Dusp1, Dusp4, Dusp5, Dusp6, Gadd45a, Spry4

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