Figure 1
From: Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women
Age-correlated TSPO expression in bilateral thalamus in a mixed-sex group of 43 subjects. Whole-brain statistical parametric analysis with a machine-learning derived measure of brain age7 as the regressor of interest, controlling for sex and BMI, shows robust results in bilateral thalamus (peak MNI coordinates: X = 20, Y = − 14, Z = 4 [t = 7.05]; X = 17, Y = − 18, Z = − 4 [t = 6.1]) as well as frontal subcortical regions. T-map is displayed at puncorected < 0.001. Results were similar when using chronologic age, which was strongly correlated with brain age (r = 0.819, p < 0.001) as the regressor of interest. Additional results of SPM analysis are presented in Supplementary Fig. 1 and Table S2.
