Table 8 Toxicity comparison of our synthesized nanocomposites with CuO ad GO based nanocomposites.
Type | Materials | Animal | Mechanism of exposure | Findings | Refs |
|---|---|---|---|---|---|
In vivo | Bi2O3/CuO/GO | Swiss albino mice | 20 mg/kg dose was administered orally for 30 days | Pathology shows small black spots in liver and lungs which disappear after 30 days. According to Hematological and biochemistry results there is no significant damage is found and particles are not toxic | Present |
In vivo | rGO/Ag NC | Mice | 10 mg/kg dose was injected intraperitoneally for 7 days | According to findings, ALT, AST and creatinine increased implying a negative impact of rGO/Ag nanocomposite on liver and kidneys. Which confirms the toxic effect of green synthesized rGO/AgNC | |
In vivo | Cu NPs | Male wister rats | 50, 100 and 200 mg/kg dose administered orally for 5 days | Pathological results show that toxicity was induced in both liver and kidneys. In liver, necrosis of tissues and in kidney necrosis in proximal renal tubule as well a swelling of proximal tubule was observed | |
In vivo | CuO NPs | Male wister rats | 10, 100 and 300 mg/kg dose delivered through IP injection for 14 days | Toxicity was induced in lungs and liver with all concentration of CuO NPs. In liver, vasculature in central veins, portal triad vessels and loss of hexagonal lobules was observed. And in lungs thickening of air scars can be seen |
