Table 4 Clinical, biological and neuropsychological characteristics of patients with pathological cognitive profiles compared to the others.
pSS patients with pathological global cognitive profile (n = 17) | pSS patients without pathological global cognitive profile (n = 15) | p value | |||
|---|---|---|---|---|---|
Sjögren's syndrome characteristics | |||||
Age, years (mean ± SD, median, IQR) | 62.2 ± 10.9 | 53 [44–67] | 55.1 ± 12.0 | 44 [53–70] | 0.09# |
SGB positivity (n, %) | 13 | 87% | 13 | 87% | 1.00* |
Aabs positivity (n, %) | 6 | 35% | 6 | 40% | 0.78† |
ESSDAI ≥ 4 (n, %) | 5 | 29% | 3 | 20% | 0.69* |
ESSPRI > 4 (n, %) | 10 | 71% | 9 | 69% | 1.00* |
Systemic involvement of the disease | 11 | 65% | 4 | 27% | 0.03† |
Quality of life | |||||
QoL mild or worse than death (EQ-5D) (n, %) | 5 | 31% | 6 | 43% | 0.51† |
SF-36 PCS abnormal | 9 | 53% | 7 | 47% | 0.72† |
SF-36 MCS abnormal | 4 | 24% | 3 | 20% | 1.00* |
Fatigue | |||||
Excessive fatigue (Chalder Fatigue scale) (n, %) | 4 | 24% | 6 | 43% | 0.25† |
MFI score (mean ± SD, median [IQR]) | 53.7 ± 19.1 | 57 [37.5–64] | 55.9 ± 17.0 | 56.5 [53–70] | 0.75# |
Pain | |||||
ESSPRI (pain subcategory) (mean ± SD, median [IQR]) | 5.8 ± 3.4 | 6 [3–9] | 6.3 ± 3.0 | 8 [4–9] | 0.80° |
Psychiatric disorders | |||||
Depression (BDI) (n, %) | 7 | 44% | 5 | 36% | 0.60† |
Mild-to-severe anxiety (STAI trait) (n, %) | 6 | 35% | 4 | 27% | 0.60† |
Sleep disorders | |||||
Excessive daytime sleepiness (Epworth) (n, %) | 7 | 41% | 10 | 71% | 0.09† |
Risk for sleep apnea (Berlin questionnaire) (n, %) | 8 | 47% | 6 | 43% | 0.82† |
Insomnia (ISI > 7) (n, %) | 12 | 71% | 10 | 67% | 0.99* |
