Table 3 Biochemical parameters of experimental groups.
Biochemical parameters | Experimental groups | p | |||
|---|---|---|---|---|---|
I control (n = 15) | II CYP-induced DO (n = 15) | III PCE (n = 15) | IV CYP-induced DO + PCE (n = 15) | ||
CGRP (pg/ml) | 94 ± 5.5 | 916 ± 30* | 117 ± 4.3§ | 152 ± 9.7# | *p < 0.0001 §p < 0.0001 #p < 0.0001 |
TNF-α (pg/ml) | 95 ± 3.6 | 235 ± 5.7* | 86 ± 2.9§ | 128 ± 3.2#,&,¶ | *p < 0.0001 §p < 0.0001 #p < 0.0001 &p < 0.0001 ¶p < 0.0001 |
IL-6 (pg/ml) | 20 ± 0.9 | 95 ± 4.3* | 18 ± 1.0§ | 22 ± 1.1# | *p < 0.0001 §p < 0.0001 #p < 0.0001 |
IL-1β (pg/ml) | 108 ± 3.4 | 427 ± 13* | 102 ± 3.5§ | 97 ± 3.1# | *p < 0.0001 §p < 0.0001 #p < 0.0001 |
OCT3 (pg/ml) | 1386 ± 94 | 8999 ± 278* | 1295 ± 54§ | 1166 ± 68# | *p < 0.0001 §p < 0.0001 #p < 0.0001 |
T–H protein | 244 ± 12 | 200 ± 10* | 267 ± 9.4§ | 254 ± 11# | *p = 0.0269 §p = 0.0003 #p < 0.0044 |
HB-EGF | 178 ± 5.7 | 119 ± 3.7* | 162 ± 3.9§ | 153 ± 4.8#,& | *p < 0.0001 §p < 0.0001 #p < 0.0001 &p = 0.0013 |
NIT | 3720 ± 155 | 64,070 ± 3753* | 5189 ± 210§ | 46,051 ± 3947#,&,¶ | *p < 0.0001 §p < 0.0001 #p = 0.0001 &p < 0.0001 ¶p < 0.0001 |
MAL | 32,570 ± 1065 | 90,883 ± 2458* | 29,713 ± 968§ | 40,984 ± 1391#,&,¶ | *p < 0.0001 §p < 0.0001 #p < 0.0001 &p = 0.0023 ¶p < 0.0001 |
ZO1 (pg/ml) | 257 ± 13 | 111 ± 7.5* | 249 ± 11§ | 253 ± 13# | *p < 0.0001 §p < 0.0001 #p < 0.0001 |
Detrusor muscle | |||||
ROCK1 (pg/ml) | 1648 ± 66 | 4052 ± 153* | 1913 ± 78§ | 2197 ± 72#,& | *p < 0.0001 §p < 0.0001 #p < 0.0001 &p = 0.0013 |
VAChT (pg/ml) | 5194 ± 277 | 45,371 ± 1955* | 6103 ± 337§ | 9043 ± 358#,& | *p < 0.0001 §p < 0.0001 #p < 0.0001 &p = 0.0469 |
Urine | |||||
BDNF (pg/ml) | 152 ± 4.5 | 468 ± 30* | 131 ± 4.7§ | 238 ± 15#,&,¶ | *p < 0.0001 §p < 0.0001 #p < 0.0001 &p = 0.0040 ¶p < 0.0001 |
NGF (pg/ml) | 241 ± 10 | 1151 ± 31* | 223 ± 13§ | 487 ± 16#,&,¶ | *p < 0.0001 §p < 0.0001 #p = 0.0001 &p < 0.0001 ¶p < 0.0001 |
