Figure 1 | Scientific Reports

Figure 1

From: [18F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response

Figure 1

Schematic of Study Design. A) PSMA-expressing 22Rv1-Luc subcutaneous xenograft were implanted into NCI athymic Nu/Nu male. Upon reaching approximately 500 mm3, either control saline or the potent targeted [225Ac]-PSMA-617 was administered. Static [18F]PARPZ-PET was performed at 1 and 6 d post-therapy (n = 8), and dynamic imaging for group matched animals (n = 3). Chemical structures of A) the PARP-1 specific [18F]-PAPRZ radiotracer and B) the prostate cancer targeting [225Ac]-PSMA-617.

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