Table 2 Univariable and multivariable logistic regression analyses for associations between plasma proteins and the presence or absence of fatigue in patients with IBD (defined as by median or by the lowest (Q1) versus highest quartile (Q4) of fatigue scores).

From: Proteomic analyses do not reveal subclinical inflammation in fatigued patients with clinically quiescent inflammatory bowel disease

Protein

Univariable analysis

Multivariable analysis

OR (95% CI)

P-value

aOR (95% CI)*

P-value

Q1 versus Q4 fatigue scores

LIF-R

0.21 (0.07–0.63)

0.005

0.29 (0.09–0.94)

0.039

VEGF-A

2.42 (1.15–5.07)

0.020

2.14 (0.97–4.73)

0.061

GDNF

0.49 (0.24–0.97)

0.041

0.72 (0.34–1.51)

0.388

IL-20RA

4.72 (1.02–21.9)

0.048

4.24 (0.76–23.7)

0.100

DNER

0.39 (0.15–1.02)

0.055

1.12 (0.38–3.33)

0.839

CD5

2.16 (0.99–4.49)

0.052

2.32 (0.99–5.45)

0.053

EN-RAGE

0.64 (0.39–1.06)

0.084

0.78 (0.46–1.35)

0.376

  1. Data are presented as odds ratios (ORs) with corresponding 95% confidence intervals (CI) and P-values. Bold P-values indicate nominal P-values < 0.05 in multivariable analysis.
  2. OR odds ratio, CI confidence interval, aOR adjusted odds ratio.
  3. *Significant confounding variables included in multivariable analysis were gender (male/female) and current smoking (no/yes).