Figure 1 | Scientific Reports

Figure 1

From: Novel secretion modification region (SMR) peptide exhibits anti-metastatic properties in human breast cancer cells

Figure 1

Tumor derived extracellular vesicles (EVs) promote breast cancer cell migration and invasion. (1) Acquisition of migratory abilities. The cargo of tumor derived EVs is frequently referred to as a pro-EMT program whose transmission throughout the tumor population drives an aggressive phenotype. (2) Directional movement. EV release of chemokines encourages movement of breast cancer cells along the path most conducive with breast cancer spread. (3) Path Creation. Degradative enzymes within EVs rapidly remove ECM to clear a path for breast cancer migration and invasion. EVs have been paralleled to ‘stepping-stones’ as they adhere via heparan sulfate and express fibronectin that can be bound by integrins on the surface of migrating breast cancer cells. Created with BioRender.

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