Figure 5

Compartment model for GN-ARB community transmission. Notes: Tables 1 and 2 show baseline conditions and parameter specifications of the compartment model. Subscript “H” stands for hospital population whereas “C” for community. IH is divided into IHH and IHC for hospital- and community-acquired BSIs. The compartment S indicates that the whole cohort is susceptible to antibiotics because gram-negative bacteria are an essential part of human gut microbiota and other mucosal surfaces. Infectiousness (I) occurs after being colonised (Z) by resistant bacteria. Individuals are immediately transferred to the susceptible S(t) disease-free population compartment after full clearance of infection. The model assumes that people can be infected only by one type of resistant bacterium simultaneously, which cannot evolve. (R) compartments are for removed individuals (death).