Table 3 Analyzing factors associated with cervical cancer recurrence using Cox regression models.
Variables | Unadjusted model | Adjusted model | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | |
Age group (years) | ||||||
< 40 | Ref | – | – | Ref | – | – |
40–59 | 0.95 | 0.76,1.20 | 0.679 | 0.99 | 0.76,1.29 | 0.935 |
≥ 60 | 0.67 | 0.45,0.99 | 0.045 | 0.61 | 0.37,1 | 0.052 |
Parity (times) | ||||||
0–2 | Ref | - | - | Ref | - | - |
≥ 3 | 0.75 | 0.61,0.92 | 0.007 | 0.87 | 0.67,1.12 | 0.284 |
Miscarriage (times) | ||||||
0 | Ref | – | – | Ref | – | – |
1–2 | 1.25 | 0.99,1.58 | 0.056 | 1.17 | 0.91,1.5 | 0.226 |
≥ 3 | 1.61 | 1.22,2.13 | 0.001 | 1.65 | 1.23,2.22 | 0.001 |
Clinical stage | ||||||
I | Ref | – | – | Ref | – | – |
II | 1.37 | 1.09,1.72 | 0.007 | 1.73 | 1.24,2.41 | 0.001 |
III/IV | 1.59 | 1.15,2.19 | 0.005 | 2.04 | 1.32,3.16 | 0.001 |
Pathological type | ||||||
Squamous cell carcinoma | Ref | – | – | Ref | – | – |
Adenocarcinoma | 0.98 | 0.63,1.53 | 0.945 | 0.88 | 0.52,1.48 | 0.620 |
Others | 1.68 | 0.87,3.26 | 0.125 | 1.94 | 0.71,5.29 | 0.193 |
Level of differentiation | ||||||
Well | Ref | – | – | Ref | – | – |
Moderate | 1.09 | 0.78,1.53 | 0.600 | 1.01 | 0.71,1.44 | 0.946 |
Poor/undifferentiated | 1.49 | 0.86,2.58 | 0.152 | 1.41 | 0.78,2.52 | 0.253 |
Treatment plan | ||||||
Surgery only | Ref | – | – | Ref | – | – |
Surgery plus adjuvant therapy | 2.62 | 1.34,5.13 | 0.005 | 1.66 | 0.73,3.76 | 0.225 |
Radiotherapy only | 2.26 | 1.15,4.46 | 0.019 | 1.35 | 0.56,3.25 | 0.503 |
Chemotherapy plus radiotherapy | 4.69 | 2.34,9.38 | < 0.001 | 1.94 | 0.8,4.7 | 0.144 |
Chemotherapy only | 10.83 | 4.49,26.14 | < 0.001 | 3.62 | 1.13,11.62 | 0.03 |
Year of admission | ||||||
1992–1995 | Ref | – | – | Ref | – | – |
1996–2000 | 1.82 | 1.13,2.92 | 0.013 | 1.9 | 1.14,3.18 | 0.014 |
2001–2005 | 3.02 | 1.94,4.68 | < 0.001 | 3.05 | 1.86,4.98 | < 0.001 |