Table 2 Physicochemical and in vitro pharmacokinetic properties of 7.44.
No | Description | Value |
|---|---|---|
1 | Kinetic solubility (99% PBS, 1% DMSO) | 177 ± 8 µM |
2 | Plasma protein binding (mouse plasma, 60 min) | 98.4 ± 0.2% |
3 | Plasma stability (mouse plasma, 0–240 min) | No degradation |
4 | Hepatocyte stability (mouse hepatocytes) | 2.5 µl/min/million cells |
5 | Chemical stability in PBS (0–4 h) | No degradation |
6 | Cytochrome P450 inhibition (at 1 µM and 10 µM concentration) | See Fig. 7 |
