Figure 7

Potential of mean force \(PMF_{{{\Delta }_{k} }} \left( {r_{b - N} } \right)\) for the bosentan–tail distance \(r_{b - N}\) in slice \({\Delta }_{k}\) (\(k = 1, \ldots 12\)). \(PMF_{{{\Delta }_{k} }} \left( {r_{b - N} } \right)\) is defined in the main text. Panels (a–l) respectively show \(PMF_{{{\Delta }_{12} }} \left( {r_{b - N} } \right), \cdots ,PMF_{{{\Delta }_{1} }} \left( {r_{b - N} } \right)\). Also, \(PMF_{{{\Delta }_{13} }} \left( {r_{b - N} } \right)\) is omitted because \(PMF_{{{\Delta }_{13} }} \left( {r_{b - N} } \right)\) is similar with \(PMF_{{{\Delta }_{12} }} \left( {r_{b - N} } \right)\).