Table 4 Cox proportional hazards regression analysis of survival in all 208 patients.
From: Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection
Characteristic | RRFS | OS | DMFS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | |||||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Age | 1.01 (1.00–1.03) | .020 | 1.01 (1.00–1.03) | .041 | 1.02 (1.01–1.03) | .004 | 1.02 (1.01–1.03) | .006 | 1.02 (1.01–1.03) | .004 | 1.02 (1.01–1.03) | .007 |
Sex | 0.98 (0.71–1.35) | .882 | 0.96 (0.63–1.47) | .863 | 0.96 (0.70–1.33) | .824 | 0.94 (0.61–1.44) | .765 | 1.01 (0.73–1.40) | .949 | 1.06 (0.69–1.62) | .800 |
Cigarette use | 1.03 (0.78–1.36) | .840 | 1.24 (0.80–1.91) | .331 | 1.02 (0.77–1.34) | .909 | 1.28 (0.82–1.99) | .279 | 1.06 (0.81–1.40) | .667 | 1.35 (0.87–2.12) | .183 |
Alcohol consumption | 0.85 (0.64–1.13) | .262 | 0.74 (0.50–1.11) | .150 | 0.84 (0.63–1.11) | .212 | 0.72 (0.48–1.08) | .114 | 0.88 (0.66–1.17) | .371 | 0.77 (0.51–1.15) | .766 |
pT status | .586 | .694 | .446 | .541 | .370 | .517 | ||||||
pT1 | 0.80 (0.50–1.30) | .375 | 0.85 (0.51–1.39) | .508 | 0.69 (0.43–1.12) | .132 | 0.71 (0.43–1.17) | .180 | 0.71 (0.44–1.14) | .157 | 0.74 (0.45–1.21) | .227 |
pT2 | 0.83 (0.56–1.22) | .347 | 0.83 (0.55–1.24) | .362 | 0.80 (0.54–1.18) | .266 | 0.79 (0.52–1.43) | .245 | 0.83 (0.56–1.23) | .354 | 0.82 (0.55–1.24) | .351 |
pT3 | 1.02 (0.64–1.64) | .927 | 1.01 (0.62–1.64) | .966 | 0.91 (0.57–1.46) | .693 | 0.88 (0.55–1.43) | .614 | 1.02 (0.64–1.64) | .928 | 1.00 (0.62–1.61) | .993 |
pT4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Primary site | .387 | .348 | .221 | .375 | .144 | .332 | ||||||
Oral cavity | 0.81 (0.57–1.16) | .252 | 0.78 (0.47–1.28) | .323 | 0.79 (0.55–1.12) | .183 | 0.84 (0.51–1.39) | .501 | 0.75 (0.54–1.07) | .112 | 0.79 (0.48–1.30) | .353 |
Oropharynx | 0.99 (0.63–1.56) | .959 | 1.15 (0.71–1.88) | .577 | 1.03 (0.65–1.63) | .904 | 1.23 (0.75–2.01) | .416 | 1.00 (0.63–1.59) | .992 | 1.19 (0.73–1.94) | .494 |
Hypopharynx | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
High-risk factors in the primary site | .212 | .309 | .090 | .150 | .107 | .222 | ||||||
Perineural invasion | 0.31 (0.04–2.22) | .241 | 0.27 (0.04–2.03) | .204 | 0.21 (0.03–1.51) | .120 | 0.18 (0.02–1.38) | .100 | 0.24 (0.03–1.76) | .162 | 0.21 (0.03–1.59) | .131 |
Lymphovascular invasion | 0.51 (0.05–5.61) | .578 | 0.38 (0.03–4.46) | .441 | 0.40 (0.04–4.45) | .455 | 0.29 (0.02–3.39) | .321 | 0.44 (0.04–4.84) | .498 | 0.29 (0.03–3.48) | .332 |
Positive margin | 0.82 (0.08–7.91) | .862 | 0.63 (0.06–6.63) | .698 | 0.62 (0.06–6.03) | .681 | 0.47 (0.05–4.98) | .532 | 0.75 (0.08–7.30) | .806 | 0.51 (0.05–5.43) | .575 |
None | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
PORT to the neck | 1.04 (0.78–1.38) | .784 | 1.26 (0.82–1.93) | .296 | 0.95 (0.72–1.26) | .725 | 1.11 (0.72–1.69) | .642 | 0.95 (0.72–1.26) | .717 | 1.15 (0.75–1.78) | .523 |
