Table 2 EV inflammatory proteins significantly associated with mortality, poverty status, race, and sex.
From: Association of extracellular vesicle inflammatory proteins and mortality
Protein symbol | Mortality | Poverty status | Race | Sex | ExoCarta/Vesiclepedia | Protein function | Reference |
|---|---|---|---|---|---|---|---|
4E-BP1 | x | x | Yes | RNA metabolism | |||
CCL4 | x | Chemokine; chemoattractant of immune, endothelial and other cells | |||||
CCL11 | x | Chemokine; immune response in inflammatory-related and allergic diseases | |||||
CCL19 | x | Chemokine; lymphoid organization, immune response initiation, immune cell trafficking | |||||
CCL23 | x | x | Chemokine; chemoattractant of immune cells in tumors | ||||
CD5 | x | Yes | Scavenger receptor; immunomodulatory function, pattern recognition receptors | ||||
CD8A | x | Yes | Cell surface receptor on cytotoxic T cells; mediates immune cell–cell interactions | ||||
CSF-1 | x | Yes | Cytokine; differentiation, proliferation, migration, function of myeloid progenitor cells | ||||
CST5 | x | x | Yes | Type 2 cystatin; cysteine proteinase inhibitor | |||
CXCL5 | x | Chemokine; promotes angiogenesis and tumorigenesis, remodels connective tissue | |||||
CXCL6 | x | Chemokine; recruits neutrophils for anti-microbial actions | |||||
CXCL9 | x | x | Chemokine; immune cell differentiation, migration and activation | ||||
CXCL10 | x | Pro-inflammatory chemokine; inflammation and response to infection | |||||
CXCL11 | x | x | x | Pro-inflammatory chemokine; inflammation and response to infection | |||
DNER | x | Yes | Neuron-specific receptor for Notch; promotes tumorigenesis in other tissues | ||||
FGF-19 | x | Yes | Endocrine factor; metabolism, protein synthesis, carcinogenesis | ||||
GDNF | x | Neurotrophic factor; neuroinflammation | |||||
IL-12B | x | x | x | Cytokine; sustains immune responses against pathogens and other immune functions | |||
MCP-1 | x | Chemokine; potential marker of biological age | |||||
MCP-2 | x | Chemokine; promotes cancer cell proliferation and migration | |||||
MMP-1 | x | Yes | Breaks down extracellular matrix proteins in physiological and pathological processes | ||||
OPG | x | Secreted receptor in TNF superfamily; bone remodeling and homeostasis | |||||
SCF | x | Binds to c-Kit receptor and regulates hematopoiesis and melanogenesis | |||||
STAMBP | x | Yes | Regulates intracellular cargo trafficking in the endosomal pathway | ||||
VEGFA | x | x | Yes | Mitogen that acts on endothelial cells and promotes vasculogenesis, angiogenesis |
