Table 6 The univariate and multivariate analysis for the PFI.

From: Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model

Characteristics

Total(N)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value*

Hazard ratio (95% CI)

P value*

T stage

T1&T2

277

Reference

 

NA

NA

T3&T4

93

2.177 (1.590–2.980)

 < 0.001

0.557 (0.125–2.490)

0.444

N stage

N0

254

Reference

   

N1

4

1.370 (0.338–5.552)

0.659

  

M stage

M0

268

Reference

 

NA

NA

M1

4

3.476 (1.091–11.076)

0.035

1.342 (0.381–4.730)

0.647

Pathologic stage

Stage I&II

259

Reference

 

NA

NA

Stage III&IV

90

2.201 (1.591–3.046)

 < 0.001

2.643 (0.590–11.843)

0.204

Tumor status

Tumor free

202

Reference

 

NA

NA

With tumor

152

11.342 (7.567–17.000)

 < 0.001

14.440 (8.484–24.580)

 < 0.001

Gender

Male

252

Reference

   

Female

121

1.018 (0.747–1.387)

0.909

  

Age

 ≤ 60

177

Reference

   

 > 60

196

0.960 (0.718–1.284)

0.783

  

BMI

 ≤ 25

177

Reference

   

 > 25

159

0.936 (0.689–1.272)

0.673

  

Residual tumor

R0

326

Reference

   

R1&2

18

1.513 (0.840–2.726)

0.168

  

Histologic grade

G1

55

Reference

   

G2

178

1.167 (0.750–1.815)

0.494

  

G3&G4

135

1.293 (0.824–2.031)

0.264

  

AFP(ng/ml)

 ≤ 400

215

Reference

   

 > 400

64

1.045 (0.698–1.563)

0.832

  

Albumin(g/dl)

 < 3 5

69

Reference

   

 ≥ 3 5

230

0.911 (0.618–1.341)

0.636

  

Prothrombin time

 ≤ 4

207

Reference

   

 > 4

89

1.100 (0.785–1.541)

0.581

  

Child–Pugh grade

A

218

Reference

   

B

21

1.423 (0.761–2.661)

0.270

  

C

1

1.156 (0.161–8.313)

0.885

  

Fibrosis ishak score

0

75

Reference

   

1/2

31

1.420 (0.799–2.524)

0.232

  

3/4

28

1.353 (0.746–2.451)

0.319

  

5/6

80

1.345 (0.861–2.101)

0.193

  

Vascular invasion

No

208

Reference

 

NA

NA

Yes

109

1.676 (1.196–2.348)

0.003

1.536 (1.009–2.337)

0.045

MMP1

 

373

1.305 (1.169–1.457)

 < 0.001

1.204 (1.003–1.446)

0.047

  1. PFI progress free interval, CI confidence interval, NA reference group or could not be evaluated. *Compared with each group (Log-Rank test or Omnibus test for univariate, Cox regression analysis with adjusted hazard for multivariate). p < 0.05 means statistically significant (highlighted in bold).
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