Figure 6

Methylation distribution analysis in the CpG context of the ZE, normal and abnormal SE by WGBS. (A) Histogram of CpG coverage for ZE, normal and abnormal SE showing normal distribution for all the samples. (B) Histogram of frequencies of CpG percentages in ZE, normal and abnormal SE showing bimodal distribution in all the samples. (C) Plot of percentages of significative regions with hypo and hypermethylation in the ten chromosomes comparing the DNA methylomes between ZE, normal and abnormal SE. (D) Hierarchical clustering of the samples by ward method, where normal and abnormal SE were grouped in the same cluster while ZE is grouped separately. (E) Bar chart of methylation levels proportion between ZE and normal and abnormal SE showing similar proportion for hypomethylation and hypermethylation in whole epigenome. Codes NSE (Normal SE) and ASE (Abnormal SE) in (E).