Figure 3

The time-dependent observations of liver lobules. Left panels: experimentally obtained 2-dimensional images of tissue sections (a, d, g, j, and m). Centre panels are computationally simulated results (b, e, h, k, and n). The right panels also show simulated results without hepatocytes (c, f, i, l, and o). The filled and open triangles indicate portal and central veins, respectively. In the simulation results, each agent is shown in different colours; hepatocytes (brown), dead cells (grey), and collagens secreted from myofibroblasts and portal fibroblasts (blue and green).