Figure 1

Skin structure in mice fetuses. (a) H&E staining, Scale bar = 100 µm. (b) SEM image, Scale bar = 200 µm. Skin appendages were not observed in E13 wounds, but epidermal skin texture was present. At later developmental stages, the skin texture was deep and clearly formed. In E14 wounds, placodes and dermal condensation were observed, indicating the onset of hair follicle formation. Hair follicles began to appear from E15. From E16 onward, the tissue structure was equivalent to that of adult mice. Green arrow: cohesive part of the dermis (placode formation).