Table 2 Patient characteristics on admission according to a three-group classification of change in Ret-He levels between admission and discharge.

From: Clinical utility of reticulocyte hemoglobin equivalent in patients with heart failure

Variable

Group 1

ΔRet-He ≦ − 2 pg (n = 17)

Group 2

 − 2 pg < ΔRet-He < 2 pg (n = 36)

Group 3

2 pg ≦ ΔRet-He (n = 35)

P value

Age (years)

78 (74–82)

76 (72–84)

75 (68–82)

0.303

Men, n (%)

10 (59)

23 (64)

25 (71)

0.631

BMI (kg/m2)

21.4 (19.6–23.9)

22.6 (21.0–24.9)

24.0 (22.1–27.9)

0.044

SBP (mmHg)

131 (126–143)

119 (109–142)

129 (124–148)

0.147

HR (bpm)

69 (61–81)

81 (67–98)

85 (69–105)

0.081

NYHA functional class III/IV, n

16 (94)

33 (92)

34 (97)

0.608

Past HF, n (%)

8 (47)

15 (42)

20 (57)

0.421

HT, n (%)

16 (94)

30 (83)

24 (69)

0.077

DM, n (%)

6 (35)

19 (53)

14 (40)

0.393

AF, n (%)

4 (24)

8 (22)

17 (49)

0.040

OMI, n (%)

8 (47)

11 (31)

10 (29)

0.381

CVD, n (%)

2 (12)

3 (8)

5 (14)

0.731

eGFR (mL/min/1.73m2)

31 (19–50)

51 (32–69)

57 (38–67)

0.077

LVEF (%)

36 (27–55)

37 (29–60)

35 (24–51)

0.504

BNP (pg/mL)

1050 (352–2470)

644 (426–974)

640 (519–1390)

0.325

Alb (g/dL)

3.2 (2.9–3.9)

3.4 (3.1–3.7)

3.3 (3.1–3.7)

0.563

Hb (g/dL)

10.3 (8.7–10.9)

10.7 (10.1–11.4)

10.6 (9.5–12.0)

0.403

MCV (fL)

93.7 (88.9–98.6)

92.6 (88.4–97.1)

92.1 (86.4–96.0)

0.450

MCH (pg)

31.1 (30.0–33.3)

30.6 (28.7–32.2)

30.6 (27.7–31.4)

0.315

MCHC (%)

33.3 (32.7–33.6)

32.8 (32.2–33.7)

33.0 (31.5–33.7)

0.271

Fe (µg/dL)

54 (38–65)

44 (35–62)

34 (24–53)

0.132

TIBC (µg/dL)

235 (201–286)

255 (232–332)

297 (233–344)

0.073

TSAT (%)

19.2 (13.0–34.9)

18.2 (12.5–22.8)

11.1 (8.3–19.3)

0.034

Ferritin (μg/L)

176 (89–437)

121 (63–228)

79 (31–193)

0.052

Ret-He (pg)

36.6 (32.9–39.0)

32.3 (31.1–34.2)

31.2 (26.6–32.3)

 < 0.001

β-blockers, n (%)

13 (76)

23 (64)

23 (66)

0.646

ACE-Is/ARBs, n (%)

10 (59)

22 (61)

21 (60)

0.987

Ca blockers, n (%)

10 (59)

11 (31)

8 (23)

0.032

Loop diuretics, n (%)

5 (29)

20 (56)

18 (51)

0.191

  1. Continuous variables are presented as median and interquartile range, and categorical variables are presented as number (percentage). ΔRet-He the change of Ret-He levels between admission and discharge, BMI body mass index, SBP systolic blood pressure, HR heart rate, Past HF past hospitalization for heart failure, HT hypertension, DM diabetes mellitus, AF atrial fibrillation, OMI old myocardial infarction, CVD cerebrovascular disease, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, BNP brain natriuretic peptide, Alb albumin, Hb hemoglobin, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, TIBC total iron binding capacity, TSAT transferrin saturation, Ret-He reticulocyte hemoglobin equivalent, ACE-I angiotensin-converting enzyme inhibitor, ARB angiotensin II receptor blocker.
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