Figure 1
From: Molecular neurobiological markers in the onset of sodium appetite
Schematic representation of different areas and mechanisms implicated in the regulation of sodium appetite after sodium depletion. Panel of AT1 neuron: AngII released after SD binds to the AT1 receptor activating the intracellular MAPK pathway to trigger sodium appetite. Osmosensitive neuron panel: changes in osmolarity, induced by SD, modify cell volume and the activity of TRPV1 channel that modulates sodium preference. DRN: dorsal raphe nucleus, LPBN: lateral parabrachial nucleus, SON: supraoptic nucleus, PVN: paraventricular nucleus, OVLT: oraganum vasculosum of the lamina terminalis; AV3V: anteroventral third ventricle area; SFO: subfornical organ, MAPK: mitogen-activated protein kinase, IP3: Inositol trisphosphate, DAG: diacylglycerol, AT1: angiotensinerigic receptor type 1, TRPV1: Transient receptor potential vanilloid subtype 1. Osm: Osmolarity, ANGII: Angiotensin II, ALDO: aldosterone.
