Figure 1 | Scientific Reports

Figure 1

From: Streptococcus suis TrpX is part of a tryptophan uptake system, and its expression is regulated by a T-box regulatory element

Figure 1

Comparative in silico analysis of TrpX protein with homologs of other bacterial species. (a) Alignment of the amino acid sequences of the protein encoded by SSU1307 (locus tag in P1/7 genome) in S. suis strain 10 (locus tag: GPW51_RS06655) and the homologous proteins of S. pneumoniae (UniProtKB A0A0H2UPV6), S. pyogenes (UniProtKB Q99ZY6), C. difficile (UniProtKB Q18A65) and V. cholerae (UniProtKB Q9KT04). Identical amino acids are shown in blue, amino acids with a similar function are marked in light pink. Green dots indicate amino acids important for substrate-binding. (b) Comparison of the in silico generated structure of TrpX (amino acids 40–332) with the crystal structure of A0A0H2UPV6 (pdb: 3lft). The computed structure of TrpX is shown as blue cartoon, whereas the reference structure is shown as grey cartoon. The ligand of A0A0H2UPV6, tryptophan, is shown in green. (c) Comparison of amino acids involved in substrate binding in A0A0H2UPV6 in cyan and the model in magenta. Tryptophan is shown in green and 3lft as cartoon in grey.

Back to article page