Figure 3
From: Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome
Circadian rhythms and homeostatic maintenance of core body temperature depend on the microbiome. (A) Representative, double-plotted records of core body temperature (Tb) in SPF (left panel), GF (middle panel), and ex-GF (right panel) mice housed in a 12L:12D photocycle (LD). Actogram annotations as in Fig. 2. (B) Double-plotted Tb waveform profile (mean ± SEM Tb at 6 min intervals) of SPF, GF, and ex-GF mice in LD (top panel); mean + SEM beginning and end of nightly elevated Tb in SPF, GF and ex-GF mice in LD (bottom panel). (C) Mean + SEM Tb of SPF, GF and ex-GF mice in the dark (shaded) and light (unshaded) phases of the LD cycle. SPF: n = 18; GF: n = 15; ex-GF: n = 4. **P < 0.01, ***< 0.001 v SPF mice; #P < 0.05, ##P < 0.01, ###P < 0.001 v GF mice.
