Figure 2 | Scientific Reports

Figure 2

From: Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13C-DHA-metabolism, altering their relationships with birthweight

Figure 2

Associations between maternal glycemia (fasting or 2 h post-load) and 13C-DHA lipid in response to myo-inositol treatment (myo-inositol response). Myo-inositol response represents the relative amount of 13C-DHA lipid in placental explants treated with myo-inositol (60 µmol/L) compared with control explants from the same placenta not treated with myo-inositol. Positive values for myo-inositol response (log2-fold-change) indicate an increase in 13C-DHA lipids compared with control (= 0), whilst negative values indicate a decrease. Linear regression was run with myo-inositol response as the outcome and maternal glycemia as the exposure/predictor variable. The Benjamini-Hochberg (BH) method was used to correct for multiple testing. Solid lines show statistically significant associations, while dashed lines show non-significant trends. Shaded areas show 95% confidence intervals. Black: Normal BMI (< 23 kg/m2), Blue: overweight (BMI 23 to < 27.5 kg/m2), Pink: obese (BMI ≥ 27.5 kg/m2).

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