Table 1 Associations between BMI or maternal glycemia (fasting, 2 h post-load) with ¹³C-DHA lipid in response to myo-inositol treatment (myo-inositol response).

From: Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental ¹³C-DHA-metabolism, altering their relationships with birthweight

¹³C-lipid	Associations between BMI and myo-inositol response^a		Associations between fasting glycemia and myo-inositol response^a		Associations between 2 h glycemia and myo-inositol response^a
¹³C-lipid	Estimate (CI)^b, unit/(kg/m²)	P (BH) value	Estimate (CI)^b, unit/(mmol/L)	P (BH) value	Estimate (CI)^b, unit/(mmol/L)	P (BH) value
DG 38:6	− 0.045 (− 0.095,0.005)	0.081	− 0.313 (− 0.851,0.226)	0.238	− 0.088 (− 0.24,0.064)	0.248
DG 40:7	− 0.049 (− 0.105,0.007)	0.083	− 0.499 (− 1.065,0.067)	0.08	− 0.119 (− 0.284,0.046)	0.146
DG 40:8	− 0.043 (− 0.087,0.001)	0.056	− 0.339 (− 0.807,0.128)	0.143	− 0.081 (− 0.216,0.054)	0.218
LPC 22:6	− 0.091 (− 0.167,− 0.016)	0.022	− 0.503 (− 1.37,0.364)	0.238	− 0.13 (− 0.377,0.116)	0.289
LPE 22:6	− 0.098 (− 0.213,0.016)	0.095	− 0.517 (− 1.762,0.728)	0.396	− 0.031 (− 0.391,0.33)	0.872
PC 38:6	− 0.097 (− 0.17,− 0.025)	0.017‡	− 0.29 (− 1.184,0.603)	0.542	0.017 (− 0.239,0.273)	0.887
PE-P 38:6	− 0.095 (− 0.154,− 0.036)	0.004^†‡	− 0.592 (− 1.313,0.129)	0.107	− 0.175 (− 0.376,0.027)	0.1
PE-P 40:6	− 0.08 (− 0.142,− 0.018)	0.017	− 0.597 (− 1.286,0.092)	0.087	− 0.171 (− 0.365,0.023)	0.09
TG 54:6	− 0.066 (− 0.121,− 0.011)	0.03	− 0.649 (− 1.205,− 0.093)	0.03	− 0.228 (− 0.366,− 0.09)	0.005^§
TG 54:7	− 0.072 (− 0.148,0.004)	0.07	− 0.738 (− 1.503,0.027)	0.06	− 0.265 (− 0.461,− 0.069)	0.014
TG 56:6	− 0.066 (− 0.119,− 0.013)	0.021^†	− 0.729 (− 1.233,− 0.225)	0.008^§	− 0.152 (− 0.313,0.01)	0.076
TG 56:7	− 0.066 (− 0.12,− 0.013)	0.018^†	− 0.778 (− 1.266,− 0.29)	0.004^§	− 0.185 (− 0.337,− 0.032)	0.021
TG 56:8	− 0.071 (− 0.121,− 0.02)	0.01	− 0.631 (− 1.172,− 0.091)	0.025	− 0.189 (− 0.337,− 0.04)	0.018
TG 56:9	− 0.071 (− 0.14,− 0.002)	0.054	− 0.821 (− 1.476,− 0.166)	0.019	− 0.243 (− 0.424,− 0.063)	0.016
TG 58:8	− 0.077 (− 0.145,− 0.009)	0.035	− 0.698 (− 1.409,0.013)	0.058	− 0.206 (− 0.404,− 0.008)	0.052
TG 58:9	− 0.074 (− 0.147,0)	0.051	− 0.948 (− 1.616,− 0.279)	0.009^§	− 0.276 (− 0.461,− 0.091)	0.006
TG 58:10	− 0.065 (− 0.125,− 0.006)	0.034	− 0.832 (− 1.366,− 0.298)	0.005^§	− 0.226 (− 0.381,− 0.071)	0.007

DG: diacylglycerols, DHA: docosahexaenoic acid, LPC: lyso-phosphatidylcholine, LPE: lyso-phosphatidylethanolamine, PC: phosphatidylcholine, PE: phosphatidylethanolamine, PE-P: phosphatidylethanolamine plasmalogen, TG: triacylglycerol.
^†Statistically significant after adjusting for fasting glycemia, ^‡Statistically significant after adjusting for post-load glycemia (2 h), ^§Statistically significant after adjusting for BMI.
^aMyo-inositol response represents the relative amount of ¹³C-DHA lipid in placental explants treated with myo-inositol (60 µmol/L) for 48 h compared with control explants from the same placenta not treated with myo-inositol.
^bLinear regression was run with myo-inositol response as the outcome. The Benjamini-Hochberg (BH) method was used to correct for multiple testing.

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Table 1 Associations between BMI or maternal glycemia (fasting, 2 h post-load) with ¹³C-DHA lipid in response to myo-inositol treatment (myo-inositol response).

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