Table 2 Association of basal lipid processing capacity in control explants with myo-inositol response and the association of myo-inositol response with birthweight centile.

From: Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental ¹³C-DHA-metabolism, altering their relationships with birthweight

¹³C-lipid	(A) Associations between basal lipid processing capacity and myo-inositol response^a		(B) Associations between birthweight centile and myo-inositol response^a
¹³C-lipid	Estimate (CI), unit/(mmol/L)	P (BH) value	Estimate (CI), unit/(mmol/L)	P (BH) value
DG 38:6	− 0.055 (− 0.309,0.2)	0.964	− 29.127 (− 61.459,3.205)	0.074
DG 40:7	− 0.063 (− 0.347,0.22)	0.722	− 29.09 (− 57.288,− 0.892)	0.044
DG 40:8	− 0.047 (− 0.274,0.18)	0.666	− 30.132 (− 67.089,6.825)	0.103
LPC 22:6	− 0.055 (− 0.466,0.357)	0.982	− 15.748 (− 36.423,4.928)	0.125
LPE 22:6	− 0.203 (− 0.772,0.365)	0.916	− 9.201 (− 24.349,5.947)	0.215
PC 38:6	− 0.4 (− 0.748,− 0.052)	0.054	− 19.848 (− 39.49,− 0.207)	0.048
PE-P 38:6	− 0.31 (− 0.626,0.006)	0.108	− 25.267 (− 46.969,− 3.565)	0.025
PE-P 40:6	− 0.188 (− 0.518,0.142)	0.488	− 23.876 (− 47.143,− 0.61)	0.045
TG 54:6	− 0.224 (− 0.497,0.05)	0.204	− 23.299 (− 51.386,4.789)	0.097
TG 54:7	− 0.202 (− 0.579,0.175)	0.542	− 11.715 (− 34.376,10.946)	0.288
TG 56:6	− 0.27 (− 0.521,− 0.018)	0.074	− 29.832 (− 56.908,− 2.756)	0.033
TG 56:7	− 0.243 (− 0.505,0.019)	0.134	− 31.392 (− 57.644,− 5.14)	0.022
TG 56:8	− 0.308 (− 0.545,− 0.07)	0.028	− 28.624 (− 56.175,− 1.074)	0.043
TG 56:9	− 0.302 (− 0.622,0.019)	0.126	− 18.045 (− 41.682,5.592)	0.125
TG 58:8	− 0.353 (− 0.664,− 0.043)	0.056	− 27.042 (− 47.422,− 6.662)	0.013
TG 58:9	− 0.456 (− 0.747,− 0.164)	0.01	− 22.52 (− 43.147,− 1.892)	0.034
TG 58:10	− 0.311 (− 0.58,− 0.041)	0.054	− 20.887 (− 47.51,5.735)	0.115

DG: diacylglycerols, DHA: docosahexaenoic acid, LPC: lyso-phosphatidylcholine, LPE: lyso-phosphatidylethanolamine, PC: phosphatidylcholine, PE: phosphatidylethanolamine, PE-P: phosphatidylethanolamine plasmalogen, TG: triacylglycerol.
^aMyo-inositol response represents the relative amount of ¹³C-DHA lipid in placental explants treated with myo-inositol (60 µmol/L) compared with control explants from the same placenta not treated with myo-inositol. (A) Linear regression was run with myo-inositol response (log2-fold-change) as the outcome and basal lipid processing (calculated by the formula (¹³C-DHA/(¹³C-DHA + ¹²C-DHA)) Z-score, log2 transformed) as the predictor variable. Basal lipid processing capacity was measured in control explants with no additional myo-inositol. (B) Linear regression was run with birthweight centile as the outcome and myo-inositol response as the predictor variable. Birthweight centile was standardized for sex and gestational age using local references^65,66. The Benjamini-Hochberg (BH) method was used to correct for multiple testing.

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Table 2 Association of basal lipid processing capacity in control explants with myo-inositol response and the association of myo-inositol response with birthweight centile.

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