Figure 3 | Scientific Reports

Figure 3

From: Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Figure 3

Propranolol modulates epidermal growth factor-induced actin cytoskeleton reorganization and stress fiber formation in osteosarcoma cells. Representative images of MG-63 cells stained with AlexaFluor555-conjugated phalloidin (red) after exposure to saline vehicle (unstimulated control), epidermal growth factor (EGF) (control), and PPN 10 or 50 µM, in addition to EGF stimulation. Nuclei were counterstained with DAPI (blue). Actin fluorescent staining in MG-63 cells grown was assessed by confocal laser scanning microscopy. Insets contain enlarged representative cells indicated by dashed squares. (×630 magnification. Scale bar = 20 µm).

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