Figure 5

Cavitation dose analysis in our in vivo trials over 150 s of sonication. (a) In trial #1 where three foci were sequentially sonicated in a repeated manner, values of ICD and SCDh in focus 2 were greater after MBs administration, while focus 1 and focus 3 were comparable to baseline. Threshold analysis revealed that a total of 20% of sonications with focus 1 consisted of inertial activity and 66% consisted of ultra-harmonics activity that would be indicative of MBs activity (ie. at least 1 out of 23 pulses, and in some cases more than 1, resulted in inertial and ultra-harmonics activity which could be indicative of presence of MBs). (b) In trial #2, net values for ICD, SCDu and SCDh for focus 2 and focus 3, were near baseline, while echoes from focus 1 had greater values of ICD and SCDh after MBs administration. (c) In trial #3, we only sonicated using 1 focus and saw 88% of sonications above threshold in SCDu, 47% of sonications above SCDh threshold and, 1% of sonications above ICD threshold. Although average of 150 s sonication show doses comparable to baseline, in the first 70 s, SCDh and ICD were higher after MBs administration.