Figure 6

BBB opening was confirmed in MRI images and BBB opened regions overlaps with FUS focus. (a) BBB opening was confirmed in after post Gd-images. The colormap show the locations of BBB opened regions in all our in vivo trials. (b) Presence and detection of large ventricle and other features present in both power Doppler image and MRI image enabled in point registration of red stars in Gd subtracted MRI image was to green stars in power Doppler image. (c) After registering, FUS foci were overlayed on BBB opened MRI image. The BBB opened areas were inside the FUS focus in both in our fist two in vivo trials. In our third in vivo trial, the higher intensity of opening was seen inside the focus but majority of the opening was seen outside the FUS focus.