Table 5 Prediction of EGFR mutations and activity.

From: Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study

No	Mutant	PolyPhen-2 HumDiv		PolyPhen HumVar		Provean		SIFT		FATHMM					PANTHER
		Score	Prediction	Score	Prediction	Score	Prediction	Score	Prediction	Domain Involved	Cancer		Inherited disease		PANTHER
		Score	Prediction	Score	Prediction	Score	Prediction	Score	Prediction	Domain Involved	Score	Prediction	Score	Prediction	Preservation time	Message	Pdel
1	A289D	0.996	PD	0.993	PD	−5.24	Del	0.001	D	Growth factor receptor domain	−1.01	Cancer	−0.01	T	797	PD	0.74
2	A289T	0.987	PD	0.974	PD	−3.54	Del	0.001	D	Growth factor receptor domain	−1.02	Cancer	−0.02	T	797	PD	0.74
3	A289V	0.997	PD	0.989	PD	−3.56	Del	0.001	D	Growth factor receptor domain	−1.04	Cancer	−0.04	T	797	PD	0.74
4	C620W	1	PD	0.998	PD	−10.32	Del	0	D	Growth factor receptor domain	−3.32	Cancer	0.00	T	911	PD	0.85
5	C620Y	1	PD	0.989	PD	−10.32	Del	0	D	Growth factor receptor domain	−3.3	Cancer	0.02	T	911	PD	0.85
6	E709K	0.974	PD	0.721	Pos D	−3.38	Del	0.003	D	Protein kinase−like (PK−like)	−1.93	Cancer	0.07	T	842	PD	0.78
7	G598V	0.997	PD	0.849	Pos D	−8.43	Del	0.004	D	Growth factor receptor domain	−2.26	Cancer	1.06	T	797	PD	0.74
8	H304Y	0	benign	0.005	benign	−2.01	Neut	1	T	Growth factor receptor domain	−1.02	Cancer	−0.02	T	456	PD	0.57
9	L62R	0.795	Pos D	0.553	Pos D	−2.02	Neut	0.006	D	Receptor L domain	−0.6	Passenger/Other	−1.27	T	455	PD	0.57
10	P596R	1	PD	0.999	PD	−8.44	Del	0	D	Growth factor receptor domain IV	−3.96	Cancer	−0.38	T	911	PD	0.85
11	P596S	1	PD	0.968	PD	−7.5	Del	0.005	D	Growth factor receptor domain IV	−3.93	Cancer	−0.35	T	911	PD	0.85
12	R108G	1	PD	1	PD	−5.87	Del	0.01	D	Receptor L domain	−0.81	Cancer	−1.48	T	842	PD	0.78
13	R108K	1	PD	1	PD	−2.59	Del	0.001	D	Receptor L domain	−0.78	Cancer	−1.44	T	842	PD	0.78
14	R222C	1	PD	1	PD	−6.52	Del	0	D	Growth factor receptor domain	−1.05	Cancer	−0.05	T	797	PD	0.74
15	R252C	1	PD	0.993	PD	−3.25	Del	0.025	D	Furin−like cysteine rich region	−2.74	Cancer	−2.08	D	456	PD	0.57
16	R252P	0.998	PD	0.991	PD	−3.17	Del	0.058	T	Furin−like cysteine rich region	−2.73	Cancer	−2.06	D	456	PD	0.57
17	S645C	0.999	PD	0.982	PD	−1.96	Neut	0.187	T	−	−1.07	Cancer	−0.94	T	361	Pos D	0.5
18	T263P	0.952	Pos D	0.913	PD	−1.38	Neut	0.087	T	Furin−like cysteine rich region	−2.51	Cancer	−1.85	D	176	Prob Benign	0.27
19	T363I	1	PD	0.994	PD	−5.07	Del	0.001	D	Receptor L domain	−0.96	Cancer	−1.62	D	842	PD	0.78
20	V774M	1	PD	0.994	PD	−1.61	Neutral	0.001	D	Protein kinase−like (PK−like)	−2.3	Cancer	−0.3	T	456	PD	0.57
21	L861Q	1	PD	0.993	PD	−5.29	Del	0.008	D	Protein tyrosine kinase	−1.88	Cancer	−1.59	D	797	PD	0.74
22	H773_V774dup	NA	NA	NA	NA	−10.34	Del	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA

PD probably damaging, Pos D possibly damaging, Del Deleterious, Neut Neutral, D Damaging, T Tolerated.

Back to article page

Table 5 Prediction of EGFR mutations and activity.

Search

Quick links