Table 2 Basic characteristics of the FoCus subcohort stratified into subjects taking DPP4i (T2D + DPP4i), without DPP4i treatment (T2D-DPP4i) and healthy controls.

From: Dipeptidylpeptidase (DPP)-4 inhibitor therapy increases circulating levels of anti-inflammatory soluble frizzle receptor protein (sFRP)-5 which is decreased in severe COVID-19 disease

Categorical variasbles

T2D + DPP4i (n = 23)

T2D-DPP4i (n = 46)

Healthy controls (n = 46)

p-value (T2D + DPP4i vs. T2D-DPP4i)

Sex

Male

12 (52%)

18 (39%)

27 (59%)

0.31

Female

11 (48%)

28 (61%)

19 (41%)

Inflammatory bowel disease

Yes

1 (4.3%)

3 (6.5%)

0 (0%)

0.73

No

22 (96%)

43 (93%)

46 (100%)

Cardian insufficiency

Yes

2 (9.5%)

6 (13%)

0 (0%)

0.67

No

19 (90%)

39 (87%)

46 (100%)

Apoplexy

Yes

2 (8.7%)

1 (2.2%)

0 (0%)

0.26

No

21 (91%)

44 (98%)

46 (100%)

Rheumatoid arthritis

Yes

1 (4.3%)

4 (9.5%)

0 (0%)

0.47

No

22 (96%)

38 (90%)

46 (100%)

Neuropathy

Yes

1 (4.8%)

7 (17%)

0 (0%)

0.19

No

20 (95%)

35 (83%)

46 (100%)

Periodontal disease

Yes

8 (35%)

17 (40%)

0 (0%)

0.71

No

15 (65%)

26 (60%)

46 (100%)

Liver disease

Yes

3 (13%)

8 (17%)

0 (0%)

0.65

No

20 (87%)

38 (83%)

46 (100%)

Myocardial infarction

Yes

3 (14%)

6 (13%)

0 (0%)

0.97

No

19 (86%)

40 (87%)

46 (100%)

High blood lipids

Yes

11 (50%)

24 (56%)

0 (0%)

0.66

No

11 (50%)

19 (44%)

46 (100%)

Hypertension

Yes

18 (78%)

35 (78%)

0 (0%)

0.97

No

5 (22%)

10 (22%)

46 (100%)

  1. Values of categorical variables are shown as n (%); Subjects were matched by age and gender. Wilcoxon Test; statistical significance: p < 0.05.