Figure 8 | Scientific Reports

Figure 8

From: Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats

Figure 8

Relative glucagon to pancreas and islet volume, individual (symbols) and means ± SDs. (A) Glucagon to pancreas volume, (B) Glucagon to islet volume. Week 4: CTRL-M, n = 6; HI-M, n = 8; CTRL-F, n = 7; HI-F, n = 8. Week 8: CTRL-M, n = 9; HI-M, n = 4; CTRL-F, n = 10; HI-F, n = 6. Day 2R: CTRL-M, n = 7; HI-M, n = 6; CTRL-F, n = 3; HI-F, n = 6. Week 4R: CTRL-M, n = 10; HI-M, n = 5; CTRL-F, n = 9; HI-F, n = 9. *p < 0.05, **p < 0.01, ***p < 0.001 versus control group for the same sex. Abbreviations: Glu, glucagon; HI, human insulin; P, pancreas; R, recovery (infusion-free period).

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