Table 3 Statistical description and univariate analysis in the primary cohort.

From: Development and validation of multivariate models integrating preoperative clinicopathological and radiographic findings to predict HER2 status in gastric cancer

Parameters

HER2 negative (n = 114)

HER2 positive (n = 23)

p

Hematological parameter

MCHC (g/L)

337.00 (328.00, 344.00)

326.00 (321.00, 340.00)

0.018*

CT value-related parameters

DP value mean (HU)

81.44 (71.33, 92.87)

74,85 (68.05, 81.29)

0.018*

DP value min (HU)

63.50 (50.75, 75.25)

56.00 (47.00, 61.00)

0.030*

Δmean D–N (HU)

41.52 (30.93, 52.58)

28.93 (22.94, 38.61)

0.003*

Texture parameters (AP)

Histogram width (HU)

47.00 (39.00, 55.25)

39.00 (35.00, 53.00)

0.046*

Texture parameters (PP)

75th percentile (HU)

97.00 (88.00, 108.50)

89.00 (82.00, 97.00)

0.049*

90th percentile (HU)

105.50 (95.00, 116.25)

98.00 (87.00, 106.00)

0.037*

Kurtosis

2.83 (2.57, 3.11)

3.02 (2.79, 3.27)

0.030*

Entropy

3.91 (3.71, 4.08)

3.80 (3.63, 3.97)

0.040*

Histogram width (HU)

35.50 (29.00, 43.00)

30.00 (26.00, 38.00)

0.045*

Entropy GLCM 10

6.78 (6.39, 7.19)

6.61 (6.23, 6.87)

0.031*

Entropy GLCM 13

6.52 (6.17, 6.88)

6.26 (6.07, 6.65)

0.040*

Energy GLCM 10a

11.75 (8.77, 15.65)

13.90 (11.47, 17.66)

0.027*

Energy GLCM 11a

13.01 (10.64, 17.58)

15.76 (12.77, 18.91)

0.046*

Energy GLCM 13a

14.49 (11.07, 18.20)

17.45 (13.21, 20.76)

0.030*

Variance GLCM 10

11.30 (7.72, 16.17)

8.45 (5.73, 12.79)

0.047*

Variance GLCM 12

11.36 (7.69, 16.05)

8.48 (6.04, 13.03)

0.048*

Texture parameters (DP)

Mean (HU)

80.80 (72.92, 89.53)

73.24 (66.86, 80.92)

0.006*

Mode (HU)

79.00 (72.75, 91.25)

72.00 (66.00, 80.00)

0.006*

Maximum (HU)

115.00 (104.75, 125.00)

105.00 (99.00, 115.00)

0.008*

5th percentile (HU)

60.00 (52.00, 72.25)

56.00 (49.00, 62.00)

0.033*

10th percentile (HU)

64.50 (57.00, 76.00)

60.00 (53.00, 66.00)

0.037*

25th percentile (HU)

72.00 (64.00, 82.25)

68.00 (60.00, 74.00)

0.019*

50th percentile (HU)

81.00 (73.00, 90.00)

73.00 (67.00, 80.00)

0.005*

75th percentile (HU)

89.00 (81.00, 97.00)

80.00 (74.00, 88.00)

0.004*

90th percentile (HU)

95.00 (88.00, 104.50)

87.00 (82.00, 94.00)

0.002*

  1. The data are presented as median with (1st quartile, 3rd quartile); HER2 human epidermal growth factor receptor 2, MCHC mean corpuscular hemoglobin concentration, CT computed tomography, AP arterial phase, PP portal phase, DP delayed phase, GLCM gray-level cooccurrence matrix; a× 10–3; *p < 0.05 with Mann–Whitney U test.
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