Figure 1

CDA activity and mRNA levels are significantly higher in the serum of BC patients than in that of healthy donors. (a) Scatter plot representation of CDA activity in enzymatic units/mg of protein for healthy female (in black) and healthy male (in gray) subjects. (b) Scatter plot representation of CDA activity in enzymatic units/mg of protein in matched healthy donors (in black) and BC patients (in gray). (c) Scatter plot representation of relative levels of CDA mRNA in matched healthy donors (in black) and BC patients (in gray). In (b) and (c), patients and controls were matched for age (± 4 years) and sex (5 male and 51 female subjects). For each panel, medians are represented by black horizontal lines and are indicated above each distribution. n is the number of individuals. Distributions were compared in Mann–Whitney tests or Wilcoxon matched-pairs signed-rank tests (see “Materials and methods” section). Values of p < 0.05 were considered statistically significant.