Table 1 Characteristics of the cases and their matched controls.

From: Pre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohort

 

Melanoma cases, n = 183

Controls, n = 183

Age at recruitment (years), mean (SD)

48.0 (6.55)

47.9 (6.53)

Birth cohort, n (%)

1943–1947

73 (39.9)

73 (39.9)

1948–1952

70 (38.3)

70 (38.3)

1953–1957

40 (21.9)

40 (21.9)

Recruitment year, n (%)

1991–1992

80 (43.7)

81 (44.3)

1996–1997

29 (15.8)

29 (15.8)

Age at blood sample (years), mean (SD)

55.7 (4.24)

55.7 (4.24)

Time in freezer (years), mean (SD)

11.23 (0.97)

11.21 (0.95)

Education (years), n (%)

≤ 10

43 (23.5)

54 (29.5)

11–13

57 (31.1)

55 (30.1)

≥ 14

78 (42.6)

67 (36.6)

Missing

5 (2.7)

7 (3.8)

Smoking, n (%)

Non-smoker

77 (42.1)

61 (33.3)

Former

71 (38.8)

73 (39.9)

Current

33 (18.0)

46 (25.1)

Missing

2 (1.1)

3 (1.6)

Hair color, n (%)

Black/dark brown

23 (12.6)

33 (18.0)

Brown

53 (29.0)

75 (41.0)

Blond/yellow

82 (44.8)

60 (32.8)

Red

15 (8.2)

5 (2.7)

Missing

10 (5.5)

10 (5.5)

Freckling when sunbathing, n (%)

Yes

78 (42.6)

67 (36.6)

No

103 (56.3)

111 (60.7)

Missing

2 (1.1)

5 (2.7)

No. of large asymmetric nevi on legs, n (%)

0

136 (74.3)

147 (80.3)

1

11 (6.0)

11 (6.0)

≥ 2

20 (10.9)

8 (4.4)

Missing

16 (8.7)

17 (9.3)

Residential ambient UVR

Low (northern Norway)

23 (12.6)

33 (18.0)

Medium–low (central Norway)

27 (14.8)

22 (12.0)

Medium (south-west Norway)

37 (20.2)

26 (14.2)

Highest (south-east Norway)

96 (52.5)

102 (55.7)

Missing

0

0

Lifetime no. of sunburnsa

0

15 (8.2)

24 (13.1)

1–20

39 (21.3)

42 (23.0)

21–30

34 (18.6)

24 (13.1)

31–47

45 (24.6)

45 (24.6)

48–58

26 (14.2)

21 (11.5)

59+ 

20 (10.9)

20 (10.9)

Missing

4 (2.2)

7 (3.8)

Lifetime no. of sunbathing vacationsa

0

14 (7.7)

14 (7.7)

1–29

45 (24.6)

44 (24.0)

30–62

32 (17.5)

44 (24.0)

63–104

39 (21.3)

41 (22.4)

105–143

21 (11.5)

16 (8.7)

144 + 

26 (14.2)

17 (9.3)

Missing

6 (3.3)

7 (3.8)

Lifetime no. of indoor tanning sessionsa

0

46 (25.1)

49 (26.8)

1–14

30 (16.4)

32 (17.5)

15–24

50 (27.3)

38 (20.8)

25–120

25 (13.7)

32 (17.5)

121–418

14 (7.7)

18 (9.8)

419+

17 (9.3)

14 (7.7)

Missing

1 (0.6)

0 (0)

Cumulative UVRb

0

8 (4.4)

10 (5.5)

1

15 (8.2)

18 (9.8)

2

26 (14.2)

20 (10.9)

3

15 (8.2)

31 (16.9)

4

31 (16.9)

26 (14.2)

5

34 (18.6)

25 (13.7)

6

24 (13.1)

24 (13.1)

7

15 (8.2)

15 (8.2)

8

8 (4.4)

7 (3.8)

9

3 (1.6)

5 (2.7)

10

4 (2.2)

2 (1.1)

Age at diagnosis (years), mean (SD)

60.2 (4.89)

N/A

Time from blood sampling to diagnosis (years), mean (SD)

4.44 (2.53)

N/A

Tumor thickness (mm), median (IQR)

0.9 (0.5,1.5)

N/A

Tumor thickness (mm), n (%)

T1 (≤ 1 mm)

109 (59.6)

N/A

T2 (1.01–2.0)

32 (17.5)

N/A

T3 (2.01–4.0)

22 (12.0)

N/A

T4 (> 4)

6 (3.3)

N/A

Missing

14 (7.7)

N/A

  1. Matched by age at blood sample and time in freezer.
  2. aCategorized in six categories: non-exposed and quartiles, with the upper quartile further divided into two equally sized groups.
  3. bSunbathing vacations and indoor tanning.