Table 2 Classification of fusions detected in 61 glioblastoma samples: fusions previously detected in healthy tissue (N = 6) or in cancers (N = 10).
Fusion | Detected in no. samples | Previously described in cancer | Previously described in gliomas | % of all patients included | Type of fusion |
|---|---|---|---|---|---|
Detected in healthy tissue (N = 45 samples) | |||||
KCNMB4::CNOT2 | 1 | No | No | 0.72 | In-frame |
NUP214::TMOD1 | 1 | No | No | 0.72 | Frame-shifted |
PFKFB3::RP11-563J2.2 | 3 | No | No | 2.16 | Unknown |
PID1::DNER | 1 | No | No | 0.72 | In-frame |
RP1-34H18.1::NAV3 | 10 | No | No | 7.2 | Unknown |
RP11-444D3.1::SOX5 | 29 | No | No | 21 | Unknown |
Detected in cancers (N = 14 samples) | |||||
FRS2::KIF5A | 1 | Yes | GB | 0.72 | Unknown |
EGFR::SEPTIN14 | 2 | Yes | LG & GB | 1.44 | In-frame |
FGFR3::TACC3 | 3 | Yes | LG & GB | 2.16 | In-frame |
CAPZA2::MET | 1 | Yes | No | 0.72 | In-frame |
CLIC4::SRRM1 | 2 | Yes | No | 1.44 | In-frame |
DPYSL3::JAKMIP2 | 1 | Yes | No | 0.72 | In-frame |
LANCL2::VOPP1 | 1 | Yes | No | 0.72 | Unknown |
R3HDM2::AVIL | 1 | Yes | No | 0.72 | Unknown |
RAB3IP::BEST3 | 1 | Yes | No | 0.72 | Frame-shifted |
SEC61G::EGFR | 1 | Yes | No | 0.72 | In-frame / Frame-shifted |
