Figure 1
From: Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries
Schematic of study timeline. Rats received 0–3× mTBI impacts or sham procedures spaced 24 h apart. Animals were euthanized at either 2 weeks (sham, 1× mTBI, 2× mTBI and 3× mTBI groups) or 10 weeks (sham and 2× mTBI groups), with the time point referring to time following the last mTBI/sham procedure for collection of skull bones for microCT and histology. Illustrations depict the site of impact of the weight drop model on the rat skull, from a sagittal and dorsal view, respectively. Time points were chosen based upon previous findings in this model, whereby 2× mTBI animals often showed the greatest effects compared to sham controls22,23. Created with Biorender.com.
