Figure 5
From: Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries
No changes in bone volume, surface area or thickness of the parietal bone were observed at 2 weeks after rmTBI. The parietal bone region-of-interest (ROI) consisting of 150 microCT images (a) was sampled from the mediocaudal left parietal bone, adjacent to the midline and Lambda suture margins (scale bar = 2 mm). Neither single nor repeated mTBI influenced bone volume (b, p = 0.23) or surface area (d, p = 0.35). Mean bone thickness was also not affected by injury (e, p = 0.58), as demonstrated by representative greyscale microCT images from the ROI z-stack center (f, scale bar = 500 µm). Total object volume was slightly increased in the 2 × mTBI group (c, *p < 0.05). Parietal ROIs from both hemispheres were examined but showed similar findings, hence only the left ROI is presented. N = 5–10/group; one-way ANOVAs with Tukey’s post-hoc as appropriate.
