Figure 4 | Scientific Reports

Figure 4

From: Spheroid co-culture of BMSCs with osteocytes yields ring-shaped bone-like tissue that enhances alveolar bone regeneration

Figure 4

Transplantation of bone-like tissue in a tooth-extraction mouse model. (a) The extraction sockets in the bone-like tissue implantation group showed better healing (red box area). Micro-CT (b,c) and HE staining (red box area) (c) of the extraction sockets showed that the bone mass in the bone-like tissue implantation group was higher than in unimplanted controls. BV/TV, bone volume/total volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular separation. (d) The extraction sockets of the bone-like tissue implantation group had more osteoid and mineralized bone by Goldner’s trichrome staining (red box area). Ordinary white-light microscopy (e) and polarized light microscopy (f) showed picrosirius red staining for the collagen fibers in the extraction sockets. (g,h) The bone-like tissue implantation group had more total collagen and type I collagen (red) than unimplanted controls. *P < 0.05.

Back to article page