Table 1 Demographic and clinicopathological characteristics of healthy controls and patients with malignant breast neoplasms.

From: The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms

Variable

Controls

N = 539 (%)

Patients

N = 464 (%)

p value

Age (years)

Mean ± S.D

Mean ± S.D

 
 

40.43 ± 15.62

52.89 ± 11.36

p < 0.05

Cigarette smoking

No

527 (97.8)

463 (99.8)

 

Yes

12 (2.2)

1 (0.2)

p < 0.05

Alcohol consumption

No

518 (96.1)

431 (92.9)

 

Yes

21 (3.9)

33 (7.1)

p > 0.05

Clinical stage

I + II

 

365 (78.7)

 

III + IV

 

99 (21.3)

 

Tumor size

< T2

 

215 (46.3)

 

T2

 

249 (53.7)

 

Lymph node status

N0

 

255 (55.0)

 

N1 + N2 + N3

 

209 (45.0)

 

Distant metastasis

M0

 

452 (97.4)

 

M1

 

12 (2.6)

 

Pathological grade

I

 

45 (9.7)

 

II + III

 

419 (90.3)

 

ER status

Negative

 

131 (28.2)

 

Positive

 

333 (71.8)

 

PR status

Negative

 

187 (40.3)

 

Positive

 

277 (59.7)

 

HER2 status

Negative

 

309 (66.6)

 

Positive

 

155 (33.4)

 

Ki-67

≤ 14%

 

136 (29.3)

 

> 14%

 

328 (70.7)

 
  1. The Mann–Whitney U test or Fisher’s exact test was used to compare values between controls and patients with breast cancer. ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2. Pathological grade: I, well differentiated; II, moderately differentiated; III, poorly differentiated.