Table 1 Clinicopathological characteristics of metastatic TNBC in the training and validation cohorts.
Characteristics | Total cohort N = 1962 | Training cohort N = 1369 | Validation cohort N = 593 | P value |
|---|---|---|---|---|
Year of diagnosis | ||||
2010–2013 | 959 (48.88) | 666 (48.65) | 293 (49.41) | 0.757 |
2014–2017 | 1003 (51.12) | 703 (51.35) | 300 (50.59) | |
Age at diagnosis (years) | ||||
18–40 | 196 (9.99) | 135 (9.86) | 61 (10.29) | 0.939 |
41–50 | 306 (15.60) | 217 (15.85) | 89 (15.01) | |
51–60 | 542 (27.62) | 375 (27.39) | 167 (28.16) | |
61–70 | 467 (23.80) | 322 (23.52) | 145 (24.45) | |
> 70 | 451 (22.99) | 320 (23.37) | 131 (22.09) | |
Race | ||||
White | 1330 (67.79) | 928 (67.79) | 402 (67.79) | 0.999 |
Black | 632 (32.21) | 441 (32.21) | 191 (32.21) | |
Marital status | ||||
Married | 881 (44.90) | 626 (45.73) | 255 (43.00) | 0.265 |
Unmarried | 1081 (55.10) | 743 (54.27) | 338 (57.00) | |
Histology | ||||
IDC | 1549 (78.95) | 1079 (78.82) | 470 ((79.26) | 0.826 |
ILC/Others | 413 (21.05) | 290 (21.18) | 123 (20.74) | |
Tumor stage (AJCC 7th) | ||||
T1 | 198 (10.09) | 134 (9.79) | 64 (10.79) | 0.528 |
T2 | 582 (29.66) | 412 (30.09) | 170 (28.67) | |
T3 | 372 (18.96) | 250 (18.26) | 122 (20.57) | |
T4 | 810 (41.28) | 573 (41.86) | 237 (39.97) | |
Node stage (AJCC 7th) | ||||
N0 | 381 (19.42) | 268 (19.58) | 113 (19.06) | 0.852 |
N1 | 861 (43.88) | 605 ((44.19) | 256 ((43.17) | |
N2 | 233 (11.88) | 164 (11.98) | 69 (11.64) | |
N3 | 487 (24.82) | 332 (24.25) | 155 (26.14) | |
Bone metastasis | ||||
No | 1096 (55.86) | 775 (56.61) | 321 (54.13) | 0.310 |
Yes | 866 (44.14) | 594 (43.39) | 272 (45.87) | |
Lung metastasis | ||||
No | 1189 (60.60) | 825 (60.26) | 364 (61.38) | 0.641 |
Yes | 773 (39.40) | 544 (39.74) | 229 (38.62) | |
Liver metastasis | ||||
No | 1430 (72.88) | 996 (72.75) | 434 (73.19) | 0.843 |
Yes | 532 (27.12) | 373 (27.25) | 159 (26.81) | |
Brain metastasis | ||||
No | 1765 (89.96) | 1233 (90.07) | 532 (89.71) | 0.811 |
Yes | 197 (9.93) | 136 (9.93) | 61 (10.29) | |
No. of metastatic site | ||||
1 | 1383 (70.49) | 962 (70.27) | 421 (70.99) | 0.803 |
2 | 420 (21.41) | 295 (21.55) | 125 (21.08) | |
3 | 129 (6.57) | 93 (6.79) | 36 (6.07) | |
4 | 30 (1.53) | 19 (1.39) | 11 (1.85) | |
Breast surgery | ||||
No | 1098 (55.96) | 764 (55.81) | 334 (56.32) | 0.832 |
Yes | 864 (44.04) | 605 (44.19) | 259 (43.68) | |
Radiotherapy | ||||
No | 1259 (64.17) | 884 (64.57) | 375 (63.24) | 0.571 |
Yes | 703 (35.83) | 485 (35.43) | 218 (36.76) | |
Chemotherapy | ||||
No | 370 (18.86) | 253 (18.48) | 117 (19.73) | 0.516 |
Yes | 1592 (81.14) | 1116 (81.52) | 476 (80.27) | |
