Figure 3 | Scientific Reports

Figure 3

From: Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Figure 3

(A) Structures of Cmpd 6 and (B) Cmpd 5 bound to IL17A C-terminal site and highlighted interactions. (C,D) Evidence of C-terminal importance was seen in these crystal structures with respect to positioning of His152 (C) “Extended position” of His152 in IL17A complex with Cmpd 6 (D) Overlay of Cmpd 5 (light orange structure with movement toward His152). In both (C,D) the position of the reported IL17 receptor A as bound to IL17A (PDB code 4HSA) is shown as light blue ribbon/surface.

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