Figure 2
From: Reduction of lithium induced interstitial fibrosis on co-administration with amiloride
Amiloride exposure has distinct genetic changes with 14, but not 28 days of exposure. (a, b) Masson’s Trichrome staining of kidney tissue from control, lithium alone and Lithium and Amiloride treatments for 14 or 28 days. Arrows highlight regions with collagen (blue) deposition. #Indicates dilated tubules. Scale bar 100 µm. (c, d) Quantification of collagen deposited, (e, f) Top 200 most variable genes clustered samples into their distinct treatment groups at 14, but not at 28 days. Shades of yellow–red indicate increased transcript abundances whereas shades of blue indicate decreases transcript abundances. Significance **P < 0.01, ns not significant. Data represented as mean ± sem.
