Figure 5
From: Reduction of lithium induced interstitial fibrosis on co-administration with amiloride
Amiloride exposure alters the amount of p53, p21 and pAKT in the kidney. (a) p53 protein detected using immunohistochemistry at 14 days, 28 days and 6 months in response to control, lithium only and LithiumAmiloride treatment. Arrows highlight positive staining in dilated tubules. #Indicate dilated tubules. Magnification of 400 ×. Scale bar 50 µm. (b–d) Quantification of percent positive cells using immunohistochemistry to detect p53, p21 and pAKT. Significance *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ns not significant. Data represented as mean ± sem.
